Circulin, an Antibiotic from a Member of the Bacillus circulans Group
نویسندگان
چکیده
منابع مشابه
Circulin, an antibiotic from a member of the Bacillus circulans group; bacteriological studies.
During the course of a search for new chemotherapeutic agents, a bacilus showing antibiotic properties was obtained from soil. The organism was isolated by plating dilutions of soil in nutrient agar seeded with Escherichia coli and fishing colonies which grew out surrounded by zones of inhibition. This culture, no. M-14, produces a substance1 that is active against gram-positive and gramnegativ...
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Production of a new aminoglycoside antibiotic by a mutant of Bacillus circulans.
A new aminoglycoside antibiotic, S-11-A, was isolated from the fermentation broth of the 2-deoxystreptamine negative (DOS-) mutant of Bacillus circulans S-11. The structure of S-11-A was elucidated as 1-deamino-1-hydroxyxylostasin, which contains an intermediate of DOS biosynthesis (S-11-P) and has resistance to some aminoglycoside-inactivating enzymes. This is the first finding of antibiotic p...
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15 صفحه اولIsolation of an intermediate of 2-deoxystreptamine biosynthesis from a mutant of Bacillus circulans.
Eight 2-deoxystreptamine-negative (DOS-) mutants were isolated from various strains of Bacillus circulans, normally producing butirosin, xylostasin and ribostamycin. These mutants were classified into two groups (converter and secretor) by the simple method of cosynthesis using agar plate culture. One of the cosynthetic pairs, strain S-11, an intermediate of DOS biosynthesis, S-11-P, was isolat...
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ژورنال
عنوان ژورنال: Journal of Bacteriology
سال: 1948
ISSN: 0021-9193,1098-5530
DOI: 10.1128/jb.56.6.749-754.1948